| 摘要: |
| 目前，微流体的精确线性降温是微流控技术在医学和生命科学等领域发展应用过程中面临的难题。为实现微流控芯片目标区域的线性降温，本文设计了基于热电制冷的微流体芯片温度调控系统，通过数值模拟和实验测试，实现了电流、制冷量及微流体温度之间的线性耦合响应。结果表明：常规恒定电流驱动热电制冷器时，微流体样品池降温过程线性度仅为0.598，采用单一函数非稳态电流可显著提升微流体降温的线性度，但在不同时间段仍存在冷量盈余与缺口，无法满足线性降温的精度要求。因此，将多种电流波形耦合获得了实现热电冷却微流体线性降温的非稳态过渡电流机制，最终实现了微流体在-19~26 ℃与24 ~ 42 ℃/min之间的线性降温，线性度在0.998 1以上，并通过实验验证了热电冷却微流体线性降温机制的准确性。 |
| 关键词: 热电制冷 微流控 线性降温 降温速率 非稳态电流 |
| DOI： |
| 投稿时间：2022-12-30 修订日期：2023-03-04
录用日期：2023-05-12 |
| 基金项目:国家自然科学基金(52006051，51876053),中央高校基本科研业务费专项资金(JZ2021HGTB0093)资助。 |
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| Examining the Linear Cooling Characteristics of Microfluid Based on Thermoelectric Refrigeration |
|
Wang Haoqing1, Sun Dongfang1,2, Gao Cai1, Cheng Wenlong2, Zhou Pei1, Tang Jingchun1, Zhu Junye1, Han Xue1, Zhang Mengfei1
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| (1.School of Automobile and Transportation Engineering, Hefei University of Technology;2.College of Engineering Sciences, University of Science and Technology of China) |
| Abstract: |
| Currently, the precise linear cooling of microfluidics remains a challenge in the development and application of microfluidic technology in medicine and life sciences. To realize the linear cooling of the target area on a microfluidic chip, a thermoelectric refrigeration-based temperature control system for microfluidic chips was designed, and linear coupling between the current, cooling capacity, and microfluidic temperature was achieved through numerical simulation and experimental tests. When the thermoelectric cooler was driven by a constant current, the linearity of the cooling process of the microfluidic sample cell was only 0.598. The use of a single-function transient current significantly improved the linearity of microfluidic cooling; however, cold surpluses and inadequacies still existed, which did not meet the accuracy requirements of linear cooling. Finally, a transient current mechanism to realize the linear cooling in microfluidic thermoelectric cooler devices was obtained by coupling a variety of current waveforms. Linear cooling of microfluidic between -19–26 °C and 24–42 °C/min was realized, and the linearity was above 0.9981. The linear cooling mechanism of the thermoelectric cooler for microfluidic devices was successfully verified by experimental tests. |
| Key words: thermoelectric cooling microfluidics linear cooling cooling rate transient current |
