| 摘要: |
| 在冷冻治疗中，无论对于正常组织还是病变组织，血管的存在对冷冻治疗效果影响显著，研究血管对于冷冻过程的影响机理意义重大。本文建立了一种基于柔性冷刀治疗系统的三维传热传质模型用于研究血管对冷冻过程的影响，采用周围血管半径为0.7 mm的肿瘤组织作为模拟对象，分别对距离冷刀3、6 mm及垂直方向和水平方向的血管进行研究，分析血管对于温度场的分布，﹣1、﹣8、﹣20、﹣40 ℃等值面的分布特性及组织损伤程度的影响。研究发现，血管越靠近冷刀对冷刀周围温度场的扰动越大，其中X=3 mm处的血管对温度的影响最大，而Z=﹣3 mm处的血管干扰冷冻过程，使组织损伤范围最小。血管与冷刀平行比与冷刀垂直对冷冻过程温度的影响大，但血管与冷刀平行的组织损伤范围大。 |
| 关键词: 低温外科 血管 生物传热模型 |
| DOI： |
| 投稿时间：2018-10-09 修订日期：2019-03-11
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| 基金项目:上海市科学技术委员会基金（18441909700）资助项目。 |
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| Simulation of the Effects of Blood Vessels in a Freezing Tumor |
|
Song Tao1, Liu Baolin1, Chang Zhaohua1,2, Xu Binkai1,2, Yang Chi1,2
|
| (1.Institute of Biothermal Technology, University of Shanghai for Science and Technology;2.AccuTarget Medical Pharma(Shanghai)Co., Ltd.) |
| Abstract: |
| Blood vessels have been studied as an important factor in normal tissue and tumors during cryosurgery. It is of great significance to study the effects of blood vessels during the freezing process. A three-dimensional heat transfer model based on a flexible cryoprobe was established to study the effects of blood vessel during cryosurgery. A tumor model with blood vessels (R= 0.7 mm) was utilized to study the effects of blood vessels at a distance of 3and 6 mm from flexible cryoprobe with different directions. The effects of blood vessels within a temperature distribution, at contours of ﹣1, ﹣8, ﹣20, and ﹣40 ℃, and the degree of tissue damage were analyzed. The results show that the greater the decrease in distance between the blood vessels and flexible probe, the greater the effects in temperature distribution. A blood vessel of X = 3 mm has the greatest impact on temperature distribution while a blood vessel of Z =﹣3 mm has the minimum impact on tissue damage. There is a great impact on temperature distribution when the blood vessels are parallel to the flexible cryoprobe and a great impact on tissue damage when the blood vessels are perpendicular to the flexible cryoprobe. |
| Key words: cryosurgery blood vessels bio-heat transfer model |
