To ensure that the concentration of indoor pollutants in a laboratory animal room is maintained at a low level

all-fresh-air systems with large air volumes are typically used in traditional air-conditioning systems

which results in high energy consumption for air conditioning. The fresh air volume used to control the concentration of pollutants is considerably higher than that used to control other parameters; therefore

this study proposes an air-conditioning system that realizes independent control of temperature

humidity

and pollutants. The proposed system reduces the fresh air volume and energy consumption of a heating

ventilation

and air-conditioning system. A cage-type laboratory animal room is used as an example; the purification effect of the proposed system is simulated using CFD software

and the system’s energy-saving performance is investigated. The results show that for a fresh air change rate of 8.53 h-1

the circulating air change rate is 13 h-1

and the supply circulating air temperature is 19.4 ℃，the indoor temperature

humidity

and pollutant concentration requirements can be met to ensure the normal survival of mice. Compared with the traditional all-fresh-air system

the fresh air volume and energy consumption of the proposed system is decreased by 57.4% and 47.9%

respectively.