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1. 上海理工大学生物热科学研究所
2. 上海导向医疗系统有限公司
纸质出版日期:2019
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宋涛, 刘宝林, 常兆华, 等. 血管影响肿瘤治疗效果的仿真研究[J]. 制冷学报, 2019,40(6).
Song Tao, Liu Baolin, Chang Zhaohua, et al. Simulation of the Effects of Blood Vessels in a Freezing Tumor[J]. Journal of refrigeration, 2019, 40(6).
宋涛, 刘宝林, 常兆华, 等. 血管影响肿瘤治疗效果的仿真研究[J]. 制冷学报, 2019,40(6). DOI: 10.3969/j.issn.0253-4339.2019.06.151.
Song Tao, Liu Baolin, Chang Zhaohua, et al. Simulation of the Effects of Blood Vessels in a Freezing Tumor[J]. Journal of refrigeration, 2019, 40(6). DOI: 10.3969/j.issn.0253-4339.2019.06.151.
在冷冻治疗中,无论对于正常组织还是病变组织,血管的存在对冷冻治疗效果影响显著,研究血管对于冷冻过程的影响机理意义重大。本文建立了一种基于柔性冷刀治疗系统的三维传热传质模型用于研究血管对冷冻过程的影响,采用周围血管半径为0.7 mm的肿瘤组织作为模拟对象,分别对距离冷刀3、6 mm及垂直方向和水平方向的血管进行研究,分析血管对于温度场的分布,﹣1、﹣8、﹣20、﹣40 ℃等值面的分布特性及组织损伤程度的影响。研究发现,血管越靠近冷刀对冷刀周围温度场的扰动越大,其中X=3 mm处的血管对温度的影响最大,而Z=﹣3 mm处的血管干扰冷冻过程,使组织损伤范围最小。血管与冷刀平行比与冷刀垂直对冷冻过程温度的影响大,但血管与冷刀平行的组织损伤范围大。
Blood vessels have been studied as an important factor in normal tissue and tumors during cryosurgery. It is of great significance to study the effects of blood vessels during the freezing process. A three-dimensional heat transfer model based on a flexible cryoprobe was established to study the effects of blood vessel during cryosurgery. A tumor model with blood vessels (R= 0.7 mm) was utilized to study the effects of blood vessels at a distance of 3and 6 mm from flexible cryoprobe with different directions. The effects of blood vessels within a temperature distribution
at contours of ﹣1
﹣8
﹣20
and ﹣40 ℃
and the degree of tissue damage were analyzed. The results show that the greater the decrease in distance between the blood vessels and flexible probe
the greater the effects in temperature distribution. A blood vessel of X = 3 mm has the greatest impact on temperature distribution while a blood vessel of Z =﹣3 mm has the minimum impact on tissue damage. There is a great impact on temperature distribution when the blood vessels are parallel to the flexible cryoprobe and a great impact on tissue damage when the blood vessels are perpendicular to the flexible cryoprobe.
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