节流喷口可调节式冷冻消融针的设计及模拟研究

杨迟; 宋涛; 常兆华; 刘宝林

doi:10.12465/j.issn.0253-4339.2025.04.149

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节流喷口可调节式冷冻消融针的设计及模拟研究

更新时间：2025-08-28

- 节流喷口可调节式冷冻消融针的设计及模拟研究
- Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle
- 制冷学报 2025年46卷第4期页码：149-155
- 作者机构：
  
  1.上海理工大学生物系统热科学研究所　上海　200093
  2.上海导向医疗系统有限公司　上海　200120
  3.上海建桥学院　上海　201306
- 作者简介：
  
  刘宝林，男，教授，上海理工大学生物系统热科学研究所，021-55277768，E-mail：blliuk@163.com。研究方向：低温生物医学工程。
- 基金信息：
- DOI：10.12465/j.issn.0253-4339.2025.04.149
  中图分类号： R318.52;R730.59
- 收稿日期：2024-04-08，
  
  修回日期：2024-05-13，
  
  录用日期：2024-06-11，
  
  纸质出版日期：2025-08-16
- 稿件说明：
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杨迟, 宋涛, 常兆华, 等. 节流喷口可调节式冷冻消融针的设计及模拟研究[J]. 制冷学报, 2025,46(4):149-155.

Yang Chi, Song Tao, Chang Zhaohua, et al. Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle[J]. Journal of refrigeration, 2025, 46(4): 149-155.
杨迟, 宋涛, 常兆华, 等. 节流喷口可调节式冷冻消融针的设计及模拟研究[J]. 制冷学报, 2025,46(4):149-155. DOI： 10.12465/j.issn.0253-4339.2025.04.149.

Yang Chi, Song Tao, Chang Zhaohua, et al. Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle[J]. Journal of refrigeration, 2025, 46(4): 149-155. DOI： 10.12465/j.issn.0253-4339.2025.04.149.

摘要

为有效提高在肿瘤冷冻消融治疗中冷冻过程的降温速率，设计了新型节流喷口可调节式冷冻消融针，针杆外壁温度降至-80 ℃仅需4 s，而传统节流喷口固定式冷冻消融针则需要73 s。三维传热模型仿真结果表明：120 s内冷冻消融针周围温度急剧降至-150 ℃，瞬时最快降温速率为1 500~1 575 ℃/min，达到快速降温的目的；-20 ℃等温线在60~120 s内变化范围较小（5 mm增至6.5 mm），120 s后温度变化趋于平缓，组织损伤范围增至9 mm，表明组织损伤区域范围明显增加。综合研究表明：节流喷口可调节式冷冻消融针具有更高的降温速率和更大的有效消融范围，对于冷冻消融临床治疗具有重要意义。

Abstract

In tumor cryoablation therapy

the effective improvement of the cooling rate of the freezing process is a research hotspot. In this study

a novel cryoablation needle with an adjustable throttle nozzle was designed. The external surface temperature of the needle could be reduced to -80 ℃ within just 4 s

while the traditional cryoablation needle with a fixed throttling nozzle requires 73 s. The three-dimensional heat transfer model simulation results show that the temperature around the cryoablation needle drops sharply to -150 ℃ within 120 s

and the fastest instantaneous cooling rate is 1 500-1 575 ℃/min

which achieves the purpose of rapid cooling. In addition

the -20 ℃ isotherm has a small variation range from 60 s to 120 s (increasing from 5 mm to 6.5 mm)

and the temperature changes tend to be gentle after 120 s

and the tissue damage range increases to 9 mm

indicating that the tissue damage range increases significantly. Comprehensive studies have shown that the adjustable throttling nozzle cryoablation needle has a higher cooling rate and larger effective ablation range

which is of great significance for clinical cryoablation treatment.

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references

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