The flow boiling heat transfer of R404A in a 5 mm micro-fin tube was studied. A number of flow boiling heat transfer models were selected by comparing the deviation between experimental results and theoretical calculations through a large amount of data to demonstrate the applicability of the models. The experimental conditions were as follows: The heat flux was 5–25 kW/m2

saturation temperature 0 oC

mass flow rate 200–500 kg/(m2?s)

and vapor quality 0.1–0.9. The results show that the Zhang Xiaoyan et al.’s model overestimates part of the data because of the great difference of thermophysical properties. Furthermore

the Liu Zhongliang et al.’s model underestimates the influence of the heat flux and underestimates most of the experimental data. The model proposed by S. M. Kim et al cannot reflect the decrease of the heat transfer coefficient in high vapor quality areas and its prediction accuracy is low. K. E. Gungor et al.’s model well explains the process of heat transfer inside a tube with a 27.46% mean absolute deviation; 98.18% of the predicted points is within a ±30% range and the mean absolute deviation is 8.95%after multiplied by a modified ratio1.372.