Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle

Yang Chi; Song Tao; Chang Zhaohua; Liu Baolin

doi:10.12465/j.issn.0253-4339.2025.04.149

您当前的位置：

首页 >

文章列表页 >

Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle

更新时间：2025-08-28

- Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle
- Journal of Refrigeration Vol. 46, Issue 4, Pages: 149-155(2025)
- 作者机构：
  
  1.上海理工大学生物系统热科学研究所　上海　200093
  2.上海导向医疗系统有限公司　上海　200120
  3.上海建桥学院　上海　201306
- 作者简介：
  
  Liu Baolin, male, professor, Institute of Biothermal Technology, University of Shanghai for Science and Technology, 86-21-55277768, E-mail: blliuk@163.com. Research fields: cryo-biomedical engineering.
- 基金信息：
- DOI：10.12465/j.issn.0253-4339.2025.04.149
  CLC： R318.52;R730.59
- Received：08 April 2024，
  
  Revised：13 May 2024，
  
  Accepted：11 June 2024，
  
  Published：16 August 2025
- 稿件说明：
移动端阅览
Yang Chi, Song Tao, Chang Zhaohua, et al. Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle[J]. Journal of refrigeration, 2025, 46(4): 149-155.
DOI：

Yang Chi, Song Tao, Chang Zhaohua, et al. Design and Simulation of Cryoablation Needle with Adjustable Throttle-Nozzle[J]. Journal of refrigeration, 2025, 46(4): 149-155. DOI： 10.12465/j.issn.0253-4339.2025.04.149.

摘要

为有效提高在肿瘤冷冻消融治疗中冷冻过程的降温速率，设计了新型节流喷口可调节式冷冻消融针，针杆外壁温度降至-80 ℃仅需4 s，而传统节流喷口固定式冷冻消融针则需要73 s。三维传热模型仿真结果表明：120 s内冷冻消融针周围温度急剧降至-150 ℃，瞬时最快降温速率为1 500~1 575 ℃/min，达到快速降温的目的；-20 ℃等温线在60~120 s内变化范围较小（5 mm增至6.5 mm），120 s后温度变化趋于平缓，组织损伤范围增至9 mm，表明组织损伤区域范围明显增加。综合研究表明：节流喷口可调节式冷冻消融针具有更高的降温速率和更大的有效消融范围，对于冷冻消融临床治疗具有重要意义。

Abstract

In tumor cryoablation therapy

the effective improvement of the cooling rate of the freezing process is a research hotspot. In this study

a novel cryoablation needle with an adjustable throttle nozzle was designed. The external surface temperature of the needle could be reduced to -80 ℃ within just 4 s

while the traditional cryoablation needle with a fixed throttling nozzle requires 73 s. The three-dimensional heat transfer model simulation results show that the temperature around the cryoablation needle drops sharply to -150 ℃ within 120 s

and the fastest instantaneous cooling rate is 1 500-1 575 ℃/min

which achieves the purpose of rapid cooling. In addition

the -20 ℃ isotherm has a small variation range from 60 s to 120 s (increasing from 5 mm to 6.5 mm)

and the temperature changes tend to be gentle after 120 s

and the tissue damage range increases to 9 mm

indicating that the tissue damage range increases significantly. Comprehensive studies have shown that the adjustable throttling nozzle cryoablation needle has a higher cooling rate and larger effective ablation range

which is of great significance for clinical cryoablation treatment.

关键词

Keywords

references

SABEL M S . Cryo-immunology: a review of the literature and proposed mechanisms for stimulatory versus suppressive immune responses [J ] . Cryobiology , 2009 , 58 ( 1 ): 1 - 11 .

GONDER M J , SOANES W A , SHULMAN S . Cryosurgical treatment of the prostate [J ] . Investigative Urology , 1966 , 3 ( 4 ): 372 - 378 .

O'ROURKE A P , HAEMMERICH D , PRAKASH P , et al . Current status of liver tumor ablation devices [J ] . Expert Review of Medical Devices , 2007 , 4 ( 4 ): 523 - 537 .

REWCASTLE J C , SANDISON G A , SALIKEN J C , et al . Considerations during clinical operation of two commercially available cryomachines [J ] . Journal of Surgical Oncology , 1999 , 71 ( 2 ): 106 - 111 .

CHU K F , DUPUY D E . Thermal ablation of tumours: biological mechanisms and advances in therapy [J ] . Nature Reviews Cancer , 2014 , 14 ( 3 ): 199 - 208 .

GAGE A A , BAUST J . Mechanisms of tissue injury in cryosurgery [J ] . Cryobiology , 1998 , 37 ( 3 ): 171 - 186 .

MAZUR P . Kinetics of water loss from cells at subzero temperatures and the likelihood of intracellular freezing [J ] . Journal of General Physiology , 1963 , 47 ( 2 ): 347 - 369 .

MAZUR P . Physical-chemical factors underlying cell injury in cryosurgical freezing in “Cryosurgery” [R ] . US : Thomas. Springfield IL , 1967 , 32 : 32 - 51 .

MAZUR P . The role of intracellular freezing in the death of cells cooled at supraoptimal rates [J ] . Cryobiology , 1977 , 14 ( 3 ): 251 - 272 .

MAZUR P . Fundamental cryobiology and the preservation of organs by freezing [J ] . Organ Preservation for Transplantation , 1981 , 2 : 143 - 175 .

MAZUR P . Freezing of living cells: mechanisms and implications [J ] . American Journal of Physiology , 1984 , 247 ( 3 Pt 1 ): C125 - C142 .

MERYMAN H T . Review of biological freezing [J ] . Cryobiology , 1966 , 3 : 1 - 144 .

PEGG D E . Mechanisms of freezing damage [J ] . Temperature and Animal Cells , 1987 , 3 : 363 - 378 .

SHERMAN J K . Survival of higher animal cells after the formation and dissolution of intracellular ice [J ] . The Anatomical Record , 1962 , 144 ( 3 ): 171 - 189 .

KLOSSNER D P , ROBILOTTO A T , CLARKE D M , et al . Cryosurgical technique: assessment of the fundamental variables using human prostate cancer model systems [J ] . Cryobiology , 2007 , 55 ( 3 ): 189 - 199 .

YU Qianfeng , YI Jingru , ZHAO Gang , et al . Effect of vascular network and nanoparticles on heat transfer and intracellular ice formation in tumor tissues during cryosurgery [J ] . Cryo Letters , 2014 , 35 ( 2 ): 95 - 100 .

GONZÁLEZ F J . Thermal simulation of breast tumors [J ] . Revista Mexicana de Física , 2007 , 53 ( 4 ): 323 .

GONZÁLEZ F J . Non-invasive estimation of the metabolic heat production of breast tumors using digital infrared imaging [J ] . Quantitative InfraRed Thermography Journal , 2011 , 8 ( 2 ): 139 - 148 .

YAN Jingfu , LIU Jing . Nanocryosurgery and its mechanisms for enhancing freezing efficiency of tumor tissues [J ] . Nanomedicine: Nanotechnology, Biology and Medicine , 2008 , 4 ( 1 ): 79 - 87 .

OKAJIMA J , KOMIYA A , MARUYAMA S . 24-gauge ultrafine cryoprobe with diameter of 550 μm and its cooling performance [J ] . Cryobiology , 2014 , 69 ( 3 ): 411 - 418 .

ZHAO Gang , GAO Dayong . Heating effect of thermally significant blood vessels in perfused tumor tissue during cryosurgery [J ] . Journal of Mechanics in Medicine and Biology , 2012 , 12 ( 1 ): 372 - 379 .

ZHANG Xin , CHAPAL HOSSAIN S M , ZHAO Gang , et al . Two-phase heat transfer model for multiprobe cryosurgery [J ] . Applied Thermal Engineering , 2017 , 113 : 47 - 57 .

WANG Zhen , ZHAO Gang , WANG Tao , et al . Three-dimensional numerical simulation of the effects of fractal vascular trees on tissue temperature and intracelluar ice formation during combined cancer therapy of cryosurgery and hyperthermia [J ] . Applied Thermal Engineering , 2015 , 90 : 296 - 304 .

GAGE A A . Freezing tissue to maximize injury in cryosurgery [J ] . Cryobiology , 1982 , 19 ( 6 ): 656 .

HOFFMANN N E , BISCHOF J C . The cryobiology of cryosurgical injury [J ] . Urology , 2002 , 60 ( 2 ): 40 - 49 .

VAN NIMWEGEN S A , L'EPLATTENIER H F , REM A I , et al . Nd: YAG surgical laser effects in canine prostate tissue: temperature and damage distribution [J ] . Physics in Medicine and Biology , 2009 , 54 ( 1 ): 29 - 44 .

CHANG Z , FINKELSTEIN J J , MA H , et al . Development of a high-performance multiprobe cryosurgical device [J ] . Biomedical Instrumentation & Technology , 1994 , 28 ( 5 ): 383 - 390 .

王辅明 , 刘敬禹 , 杨朝爱 , 等 . 国产冷冻设备(靶向刀)治疗肝癌临床应用 [J ] . 介入放射学杂志 , 2018 , 27 ( 6 ): 530 - 533 .

( WANG Fuming , LIU Jingyu , YANG Chaoai , et al . Clinical application of domestic cryoablation device in the treatment of liver carcinomas [J ] . Journal of Interventional Radiology , 2018 , 27 ( 6 ): 530 - 533 .)

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Initial Freezing Temperature of a New Cold Storage Material Al2O3-H2O Nanofluid

Numeral Study and Experimental Verification of Vent-Hole Type of External Cover on Differential Pressure Cooling

Experimental Characterization of the Joule-Thomson Cryostat of a Cryoprobe

Cooling Rate Measurement and System Optimization for Cryotop Device

Related Author

Yang Wenzhe

Zhao Songsong

Chen Aiqiang

Guo Heng

Liu Bin

Zhang Chensi

张梦飞

王好卿

Related Institution

Tianjin Key Laboratory of Refrigeration Technology，Tianjin University of Commerce

中国科学技术大学工程科学学院

合肥工业大学汽车与交通工程学院

上海导向医疗系统有限公司

上海理工大学能动学院，上海导向医疗系统有限公司

Address：10/F, Yindu Mansion, 67 Fucheng Road, Haidian Dist, Beijing, China Postal code：100142
Tel：010-68711412 Email：editor@car.org.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰